Published in association with the RSPCA, the UK's leading animal welfare charity, this practical family guide is full of expert advice on how to choose a puppy and how best to look after it.
Published in association with the RSPCA, the UK's leading animal welfare charity, this practical family guide is full of expert advice on how to choose a puppy and how best to look after it.
This handy birdwatching field guide is an excellent introduction to the fantastic array of birds found in Southeast Asia. Southeast Asia is home to a remarkable array of bird species-the most diverse on Earth. These birds range in size from the tiny Orange-bellied Flowerpeckers living within the rainforest, to massive White-bellied Sea-Eagles. They vary in color from drab, olive babblers, to exquisitely-hued kingfishers.
Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, "arming" mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.
The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
This is a textbook for graduate and final-year-undergraduate computer-science and electrical-engineering students interested in the hardware and software aspects of embedded and cyberphysical systems design. It is comprehensive and self-contained, covering everything from the basics to case-study implementation. Emphasis is placed on the physical nature of the problem domain and of the devices used. The reader is assumed to be familiar on a theoretical level with mathematical tools like ordinary differential equation and Fourier transforms. In this book these tools will be put to practical use. Engineering Embedded Systems begins by addressing basic material on signals and systems, before introducing to electronics. Treatment of digital electronics accentuating synchronous circuits and including high-speed effects proceeds to micro-controllers, digital signal processors and programmable logic. Peripheral units and decentralized networks are given due weight. The properties of analog circuits and devices like filters and data converters are covered to the extent desirable by a systems architect. The handling of individual elements concludes with power supplies including regulators and converters. The final section of the text is composed of four case studies: • electric-drive control, permanent magnet synchronous motors in particular; • lock-in amplification with measurement circuits for weight and torque, and moisture; • design of a simple continuous wave radar that can be operated to measure speed and distance; and • design of a Fourier transform infrared spectrometer for process applications. End-of-chapter exercises will assist the student to assimilate the tutorial material and these are supplemented by a downloadable solutions manual for instructors. The “pen-and-paper” problems are further augmented with laboratory activities. In addition to its student market, Engineering Embedded Systems will assist industrial practitioners working in systems architecture and the design of electronic measurement systems to keep up to date with developments in embedded systems through self study.
Еще совсем недавно Джон Долан был бездомным и никому не нужным. Большую часть жизни он провел на улице, терпел холод и нужду. Но однажды все изменилось благодаря собаке, которая попала к нему совершенно случайно. Теперь Джон - знаменитый художник. Он ворвался в мир искусства, подобно яркому метеориту, и в этом ему помог Джордж, стаффордширский терьер, который спас его и сделал другим человеком. Джон никогда не расстается со своей собакой. "Если бы не он, я бы никогда больше не взял в руки карандаш", говорит он. В нашей библиотеке вы можете бесплатно почитать книгу « Джон и Джордж. Пес, который изменил мою жизнь ». Чтобы читать онлайн книгу « Джон и Джордж. Пес, который изменил мою жизнь » перейдите по указанной ссылке. Приятного Вам чтения.
Трогательная история о рыжем коте из библиотеки городка Спенсер, описанная в книге Вики Майрон "Дьюи", вызвала миллионы восторженных отзывов. Читатели так прониклись атмосферой душевного тепла, которое дарил людям Дьюи, что вдохновили Вики Майрон написать продолжение. В новой книге - девять историй о котах, которые объединили людей, подарили им надежду и помогли справиться с жизненными трудностями, научили радоваться, любить и сострадать. Две истории посвящены всемирно известному Дьюи. Книга заставляет смеяться, плакать и удивляться, каким волшебным образом пушистые любимцы преображают нашу жизнь. В нашей библиотеке вы можете бесплатно почитать книгу « Девять жизней Дьюи. Наследники кота из библиотеки, который потряс весь мир ». Чтобы читать онлайн книгу « Девять жизней Дьюи. Наследники кота из библиотеки, который потряс весь мир » перейдите по указанной ссылке. Приятного Вам чтения.
Книга, которую вы сейчас держите в руках, в некотором смысле уникальна. Темы любви к животным, внимательного и милосердного отношения к «тем, кого мы приручили», касались в своем творчестве многие авторы как прошлого, так и современности. Но уже очень давно взаимоотношения людей и «меньших братьев» не становились сквозной идеей для целого сборника увлекательных рассказов. Истории, рассказанные Светланой Сафоновой, чрезвычайно актуальны. Они происходят здесь и сейчас: в вашем дворе, за соседской дверью, на ближайшей улице. Любой из нас видел персонажей этих рассказов в обычной жизни, а возможно, и был одним из них. Легкость и динамичность повествования сочетаются в них с большой психологической достоверностью. Это и неудивительно, ведь в основе большинства историй лежат подлинные случаи из жизни отечественных зоозащитников. Благодаря всему этому книга не только захватывает с первых страниц, но и делает всех нас чуточку добрей. В нашей библиотеке вы можете бесплатно почитать книгу « Кошки, собаки и… другие люди. Невыдуманные истории спасения ». Чтобы читать онлайн книгу « Кошки, собаки и… другие люди. Невыдуманные истории спасения » перейдите по указанной ссылке. Приятного Вам чтения.
"Cosa si nasconde dietro al mito del Diluvio Universale?"; "Quanto incisero le condizioni meteorologiche sullo sbarco degli alleati in Normandia?"; "Come si svolse l'inondazione di Firenze del 1966?". Domande a cui risponde, insieme a molte altre, questo agile testo che unisce al rigore della documentazione scientifica uno stile piacevole e accattivante.
From one of the most original and influential neuroscientists at work today, here is an exploration of consciousness unlike any other—as told by Galileo, who opened the way for the objectivity of science and is now intent on making subjective experience a part of science as well. Galileo’s journey has three parts, each with a different guide. In the first, accompanied by a scientist who resembles Francis Crick, he learns why certain parts of the brain are important and not others, and why consciousness fades with sleep. In the second part, when his companion seems to be named Alturi (Galileo is hard of hearing; his companion’s name is actually Alan Turing), he sees how the facts assembled in the first part can be unified and understood through a scientific theory—a theory that links consciousness to the notion of integrated information (also known as phi). In the third part, accompanied by a bearded man who can only be Charles Darwin, he meditates on how consciousness is an evolving, developing, ever-deepening awareness of ourselves in history and culture—that it is everything we have and everything we are. Not since Gödel, Escher, Bach has there been a book that interweaves science, art, and the imagination with such originality. This beautiful and arresting narrative will transform the way we think of ourselves and the world.
Does science aim at providing an account of the world that is literally true or objectively true? Understanding the difference requires paying close attention to metaphor and its role in science. In The Third Lens, Andrew S. Reynolds argues that metaphors, like microscopes and other instruments, are a vital tool in the construction of scientific knowledge and explanations of how the world works. More than just rhetorical devices for conveying difficult ideas, metaphors provide the conceptual means with which scientists interpret and intervene in the world. Reynolds here investigates the role of metaphors in the creation of scientific concepts, theories, and explanations, using cell theory as his primary case study. He explores the history of key metaphors that have informed the field and the experimental, philosophical, and social circumstances under which they have emerged, risen in popularity, and in some cases faded from view. How we think of cells—as chambers, organisms, or even machines—makes a difference to scientific practice. Consequently, an accurate picture of how scientific knowledge is made requires us to understand how the metaphors scientists use—and the social values that often surreptitiously accompany them—influence our understanding of the world, and, ultimately, of ourselves. The influence of metaphor isn’t limited to how we think about cells or proteins: in some cases they can even lead to real material change in the very nature of the thing in question, as scientists use technology to alter the reality to fit the metaphor. Drawing out the implications of science’s reliance upon metaphor, The Third Lens will be of interest to anyone working in the areas of history and philosophy of science, science studies, cell and molecular biology, science education and communication, and metaphor in general.
Despite the fact that year 2018 has recently begun, it has already been marked by a number of important events in Cosmonautics. Many important events also await us in the near future. Humanity is becoming more confident in exploring space, and Cosmonautics has long become an indispensable branch in people's lives. This book will tell you about how humanity has made its first steps in conquering outer space. About how the first rocket took off, how the first spacecraft sent its signal to Earth, how people flew into space, how different countries, such as the USA, the European Union, China, Japan, India, Russia, master space technologies, and as well as many other things related to human activities in the Earth’s orbit. The book contains more than 120 illustrations, of which more than 20 illustrations of space rockets and more than 40 illustrations of other spacecrafts, such as space ships, satellites, stations, etc. The book is intended for older children, but it will also be of interest to any adult who is interested in the modern successes of Astronautics.
This book highlights success stories and challenges to implementing health IT standards. The narrative of each chapter demonstrates how standards further interoperable health data exchange, especially in the service of advancing tools to monitor population health. These are critical stories that demonstrate to an international community of health and IT experts how to bring the right stakeholders together and bridge classic divides between software architects and clinical end users, health system decision-makers and standard authors.
Molecular Physical Chemistry: A Concise Introduction focuses on two main aspects of physical chemistry: thermodynamics and reaction dynamics. By looking at the properties of the atoms and molecules that constitute matter, it makes use of results from modern experiments conducted on small numbers of molecules. These molecular properties allow the behaviour of larger groups of molecules to be predicted. This is in contrast to conventional approaches which are based upon how the subjects have developed historically. It attempts to show how some basic concepts can be easily applied to give verifiable results in simple systems before extending them to more complicated scenarios. The text is intended as an aid to understanding these central topics of physical chemistry, rather than an introduction to them, and some familiarity with them is assumed throughout. Worked examples and problems are given at the end of each chapter. Molecular Physical Chemistry: A Concise Introduction will be welcomed by graduate and advanced undergraduate students, as well as lecturers. Upon completion of this book the reader will see its subject matter as an integral part of their whole approach to chemistry. "Professor McLauchlin is certainly owed a debt of gratitude by the chemical community for this effort to bring enjoyment and understanding to the future generation. It will be interesting to see if this experiment helps students replace the fear of physical chemistry by an appreciation of its power and beauty." Professor William Klemperer, University of Harvard
A comprehensive text on matrix theory and its applications, this book is intended for a broad range of students in mathematics, engineering, and other areas of science at the university level. Author Alexander Graham avoids a simple catalogue of techniques by exploring the concepts' underlying principles as well as their numerous applications. Many problems elucidate the text, which includes a substantial answer section at the end. The treatment explores matrices, vector spaces, linear transformations, and the rank and determinant of a matrix. Additional topics include linear equations, eigenvectors and eigenvalues, canonical forms and matrix functions, and inverting a matrix. A Solution to Problems Section, References and a Bibliography conclude the treatment.
Spirit mediums of East Africa. Healers and fishermen of the Amazon River Basin. Potters of the American Southwest. People contending with climate change long ago. All share “knowledge in motion,” a process of drawing on experiences past and present while engaging in daily practice in relation to contexts of time, place, and power. In the last twenty-five years, scholars from a number of disciplines have explored “situated learning,” specifically investigating how learning relates to social reproduction and daily life. In Knowledge in Motion, contributors focus on learning through time and at a variety of scales, particularly as they relate to power and politics, with implications for emergent communities and constellations of practice. This volume brings together archaeologists, historians, and cultural anthropologists to examine communities engaged in a range of learning practices around the globe, from Africa to the Americas. Contributors draw on the growing interdisciplinary scholarship on situated learning to explore those processes in relation to power and broader forces that shape knowledge during times of turbulent change. Enriching the diversity of regions and disciplines, Knowledge in Motion focuses on how learning, knowledge transmission, and the emergent qualities of communities and constellations of practice are shaped by changing spheres of interaction or other unstable events and influences. The contributions forge productive theories and methodologies for exploring situated learning and its broad-ranging outcomes.
In 1936 a German chemist identified certain organic molecules that he had extracted from ancient rocks and oils as the fossil remains of chlorophyll--presumably from plants that had lived and died millions of years in the past. It was another twenty-five years before this insight was developed and the term "biomarker" coined to describe fossil molecules whose molecular structures could reveal the presence of otherwise elusive organisms and processes. Echoes of Life is the story of these molecules and how they are illuminating the history of the earth and its life. It is also the story of how a few maverick organic chemists and geologists defied the dictates of their disciplines and--at a time when the natural sciences were fragmenting into ever-more-specialized sub-disciplines--reunited chemistry, biology and geology in a common endeavor. The rare combination of rigorous science and literary style--woven into a historic narrative that moves naturally from the simple to the complex--make Echoes of Life a book to be read for pleasure and contemplation, as well as education.
This book is concerned with computing in materio: that is, unconventional computing performed by directly harnessing the physical properties of materials. It offers an overview of the field, covering four main areas of interest: theory, practice, applications and implications. Each chapter synthesizes current understanding by deliberately bringing together researchers across a collection of related research projects. The book is useful for graduate students, researchers in the field, and the general scientific reader who is interested in inherently interdisciplinary research at the intersections of computer science, biology, chemistry, physics, engineering and mathematics.
Focusing on data commonly found in public health databases and clinical settings, Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology provides an overview of the main areas of Bayesian hierarchical modeling and its application to the geographical analysis of disease. The book explores a range of topics in Bayesian inference and modeling, including Markov chain Monte Carlo methods, Gibbs sampling, the Metropolis–Hastings algorithm, goodness-of-fit measures, and residual diagnostics. It also focuses on special topics, such as cluster detection; space-time modeling; and multivariate, survival, and longitudinal analyses. The author explains how to apply these methods to disease mapping using numerous real-world data sets pertaining to cancer, asthma, epilepsy, foot and mouth disease, influenza, and other diseases. In the appendices, he shows how R and WinBUGS can be useful tools in data manipulation and simulation. Applying Bayesian methods to the modeling of georeferenced health data, Bayesian Disease Mapping proves that the application of these approaches to biostatistical problems can yield important insights into data.
A psychiatrist presents a compelling argument for how human purpose and caring emerged in a spontaneous and unguided universe. Can there be purpose without God? This book is about how human purpose and caring, like consciousness and absolutely everything else in existence, could plausibly have emerged and evolved unguided, bottom-up, in a spontaneous universe. A random world--which according to all the scientific evidence and despite our intuitions is the actual world we live in--is too often misconstrued as nihilistic, demotivating, or devoid of morality and meaning. Drawing on years of wide-ranging, intensive clinical experience as a psychiatrist, and his own family experience with cancer, Dr. Lewis helps readers understand how people cope with random adversity without relying on supernatural belief. In fact, as he explains, although coming to terms with randomness is often frightening, it can be liberating and empowering too. Written for those who desire a scientifically sound yet humanistic view of the world, Lewis's book examines science's inroads into the big questions that occupy religion and philosophy. He shows how our sense of purpose and meaning is entangled with mistaken intuitions that events in our lives happen for some intended cosmic reason and that the universe itself has inherent purpose. Dispelling this illusion, and integrating the findings of numerous scientific fields, he shows how not only the universe, life, and consciousness but also purpose, morality, and meaning could, in fact, have emerged and evolved spontaneously and unguided. There is persuasive evidence that these qualities evolved naturally and without mystery, biologically and culturally, in humans as conscious, goal-directed social animals. While acknowledging the social and psychological value of progressive forms of religion, the author respectfully critiques even the most sophisticated theistic arguments for a purposeful universe. Instead, he offers an evidence-based, realistic yet optimistic and empathetic perspective. This book will help people to see the scientific worldview of an unguided, spontaneous universe as awe-inspiring and foundational to building a more compassionate society.